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at steady state, when the cyp2d6 pathway is essentially saturated, paroxetine clearance is governed by alternative p 450 isozymes that, unlike cyp2d6, show no evidence of saturation see precautions tricyclic antidepressants .
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study 2 was a 12-week flexible-dose study comparing paroxetine 10 to 60 mg daily and placebo.
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phenytoin when a single oral 30-mg dose of paxil was administered at phenytoin steady state 300 mg once daily for 14 days , paroxetine auc and t were reduced by an average of 50 and 35 , respectively compared to paxil administered alone.
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based on the mechanism of action of snris and ssris, including paroxetine hydrochloride, and the potential for serotonin syndrome, caution is advised when paroxetine is coadministered with other drugs that may affect the serotonergic neurotransmitter systems, such as triptans, lithium, fentanyl, tramadol, amphetamines, or st.
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metoclopramide exposure levels are increased when co-administered with strong cyp2d6 inhibitors such as fluoxetine and paroxetine.
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