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available evidence indicates that patients whose tumors are estrogen receptor positive are more likely to benefit from tamoxifen therapy.

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study d2407 is an open-label, randomised, multicentre post approval safety study designed to compare the effects of adjuvant treatment with letrozole and tamoxifen on bone mineral density bmd and serum lipid profiles.

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there is evidence of an increased incidence of thromboembolic events, including deep vein thrombosis and pulmonary embolism, during tamoxifen therapy.

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the decline in tamoxifen plasma concentrations is biphasic with a terminal elimination half-life of approximately 5 to 7 days.


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