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With methotrexate, risks of symptomatic and aimed at preventing further absorption from toxicity eg, stomatitis, bone marrow suppression, nephro- the gi tract; increasing urinary excretion; and correcting toxicity may be increased.

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omeprazole major use caution when administering high-dose methotrexate to patients receiving proton pump inhibitors ppis ; a temporary withdrawal of the ppi should be considered in some patients receiving high-dose methotrexate.

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due to the potential for serious adverse reactions from methotrexate in breast fed infants, breast feeding is contra-indicated in women taking methotrexate.

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